Ion Exchange Resins for Biotechnology

Thermax Chemical manufactures speciality Tulsion® polymers finds application in the biotechnology area, specifically for solid phase peptide synthesis.

Thermax products meet all stringent quality norms of the biotechnology industry like leachables, particle size, uniformity due to stringent Quality control and sophisticated instrumentation.

A brief product portfolio is presented below.

Tulsion® CB Polymers

Thermax offers Tulsion® CB 100/200 resins for solid phase organic synthesis. Tulsion® CB-100 refers to 100 to 200 US Mesh size & Tulsion® CB-200 refers to 200 to 400 US Mesh Size.

Tulsion® CB 100/200 resins have a polystyrene matrix cross-linked with 1% DVB. The swelling factor and bead size of these resins are the most important characteristics for solid phase organic synthesis with respect to specificity. The swelling characteristics depend upon the degree of cross-linking, hydrophobic nature of substrate and the matrix. Controlled Particle size & Cross-linking and offers appropriate reaction kinetics through diffusion which facilitates complete chemical conversions in shorter reaction time.

Tulsion® CB 100/200 is highly hydrophobic in nature and swells in non-polar solvents. These polymers offer mechanically stable matrix in presence of swelling solvents; which is a critical parameter in solid phase peptide synthesis.

Tulsion® CB 100/200 resins are used as a precursor for in variety of solid phase supports like e Chloromethylated Polystyrene resins or Merrifield resins (Tulsion® CMB), Wang resins, Chlorotrytil resins and other resins used in solid phase peptide synthesis.

Thermax also offers tailor-made Tulsion® CB polymers for solid phase organic synthesis as per customer requirements.

Tulsion® CMB Polymers (Merrifield Resin)

Tulsion® CMB polymers are extensively used for peptide synthesis.

Tulsion® CMB polymers have a chloromethyl functionality. The formation of peptide bond starts with the reaction of a protected amino acid molecule with chloromethyl group on the surface of polystyrene polymer. After removal of the protecting group, a new amino acid molecule is reacted to elongate the peptide chain. The elongation is continued with step-wise addition. Excess reagents and by-products are removed by filtration at each step. The final step in the synthesis involves freeing up of the protecting group as well as liberating peptide from the polymer.

Tulsion® CMB polymers (Merrifield resin) are an effective precursor for first order substituted resins. These resins offer appropriate swelling characteristics and uniform reaction kinetics due to Controlled and precise choloromethylation.

Properties of Merrifield resins can be tailor-made for particle size, substitution or cross-linking to suit individual application needs. They are made under very carefully controlled conditions using strict quality standards.

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